ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinicopathological characteristics of sporadic renal hemangioblastoma.</p><p><b>METHODS</b>Two cases of sporadic renal hemangioblastoma were studied by histological and immunohistochemical staining, along with review of the literature.</p><p><b>RESULTS</b>Both cases were presented with a renal mass during annual physical examination with an age of 40 and 45 years, respectively. The lesions located in the middle portion of the kidney with a sharp tumor border. Histopathologically, the tumors were characterized by two major components: capillary and stromal cells. Immunohistochemically, the stromal cells were positive for vimentin, NSE, S-100 protein and inhibin-α, and negative for CK, HMB45, Melan A, EMA, CD56 and syn. Both tumors showed a very low level of Ki-67 labeling. The endothelial cells were positive for CD34.</p><p><b>CONCLUSION</b>Sporadic renal hemangioblastoma is a rare benign neoplasm, the diagnosis of which is based on the characteristic follicular architecture and an exclusion of other carcinomas of the kidney.</p>
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Angiomyolipoma , Metabolism , Pathology , Antigens, CD34 , Metabolism , Carcinoma, Renal Cell , Metabolism , Pathology , Diagnosis, Differential , Follow-Up Studies , Hemangioblastoma , Diagnostic Imaging , Metabolism , Pathology , General Surgery , Immunohistochemistry , Inhibins , Metabolism , Kidney Neoplasms , Diagnostic Imaging , Metabolism , Pathology , General Surgery , Nephrectomy , Phosphopyruvate Hydratase , Metabolism , S100 Proteins , Metabolism , Tomography, X-Ray Computed , Methods , Vimentin , MetabolismABSTRACT
<p><b>OBJECTIVE</b>To investigate multiple slice computed tomography (MSCT) and magnetic resonance imaging (MRI) features of congenital stenosis of the internal auditory canal (CSIAC) and improve the ability for diagnosis.</p><p><b>METHOD</b>Thirteen cases with fifteen ears were studied. In all cases a MSCT and MRI was performed.</p><p><b>RESULTS</b>Eleven cases were unilateral, and 2 cases were bilateral. MSCT could show the narrowness of IAC. Three cases were isolated, but the others were combined with inner ear malformations. One ear had inner, middle and outer ear malformations. One ear had inner, middle, and outer ear malformations with a frontal bone malformation. MRI demonstrated that all of the vestibulocochlear nerves were hypoplastic. The cochlear nerve in seven ears was not present, in seven ears the nerve was thinner, and in the last case it was poorly visualized. The facial nerve in two ears was hypoplastic. Volume rendering (VR) could present the degree of the narrowed internal auditory canals, combined with other inner ear anomalies.</p><p><b>CONCLUSION</b>MSCT will show the degree of the narrow internal auditory canals and combined anomalies, while the MRI can further demonstrate the nerves' development.</p>
Subject(s)
Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , Male , Young Adult , Constriction, Pathologic , Diagnostic Imaging , Pathology , Ear, Inner , Congenital Abnormalities , Diagnostic Imaging , Pathology , Magnetic Resonance Imaging , Tomography, Spiral ComputedABSTRACT
<p><b>OBJECTIVE</b>To explore multiple slices computed tomography (MSCT) and magnetic resonance imaging (MRI) features of duplication of the internal auditory canal (DIAC) in order to improve the accuracy of diagnosis.</p><p><b>METHODS</b>Four cases (5 ears) were analyzed and the related documents were reviewed retrospectively. MSCT was performed on all cases, and two cases had MRI scanning at the same time.</p><p><b>RESULTS</b>MSCT has shown that the internal auditory canal were divided into two canals by a bony septum in 5 ears. The superior canal ended in a very narrow connection to the facial canal, the inferior portion ended in connection to the cochlea and vestibule. The bony septums from the 2 ears were found no longer intact. The sum of diameter of the two canals was greater than 2 mm. In addition, 5 ears were found to have an enlarged vestibules and the hypoplasia lateral semicircular canals, and meanwhile, 2 ears of them were combined with ipsilateral microtia. Also 1 case of them was combined with microtia, outer acoustic atresia as well as abnormal middle ear. Multiplanar reconstruction and volume rendering images can entirely show the bony septum and two canals. In this study, the vestibular nerve, cochlear nerve and facial nerve were total hypoplastic in one ear, in the other ear, the vestibular and cochlear nerve were hypoplastic, and however, the facial nerve was intact.</p><p><b>CONCLUSIONS</b>MSCT can clearly depict duplication of the internal auditory canals and concomitant anomalies. MRI can clearly show the neural components and their associated malformation.</p>